Slc11a2 ELISA Kit for Mouse(Mus musculus) | EIAab.comSlc11a2 ELISA Kit for Mouse(Mus musculus)

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Slc11a2 (Gene name),

Natural resistance-associated macrophage protein 2 (Protein name ), NRAM2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Slc11a2(Dct1;Dmt1;Nramp2);

Protein name:

Natural resistance-associated macrophage protein 2(NRAMP 2);

Alternative:

Divalent metal transporter 1(DMT-1);Divalent cation transporter 1;Solute carrier family 11 member 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.

Function:

Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.

Subcellular Location:

Endosome membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

568

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

568:

QPELYLLNTV | DADSVVSR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01566

KEGG:

mmu:18174

String:

P49282

UniGene:

Mm.234608

Uniprot:

P49282

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ELISA Kit for Mouse NRAMP 2

Cat.:

E0316r

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96T

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ELISA Kit for Mouse NRAMP 2

Cat.:

E0316h

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96T

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ELISA Kit for Mouse NRAMP 2

Cat.:

E0316m

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96T

CLIA Kit for Mouse NRAMP 2

Cat.:

U0316m

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96T

CLIA Kit for Mouse NRAMP 2

Cat.:

U0316h

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96T

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CLIA Kit for Mouse NRAMP 2

Cat.:

U0316r

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96T

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Polyclonal Antibody for Mouse NRAMP 2

Cat.:

P0316Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse NRAMP 2

Cat.:

P0316Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse NRAMP 2

Cat.:

P0316Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse NRAMP 2

Protein for Mouse NRAMP 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification and characterization of a second mouse Nramp gene."
Gruenheid S. , Cellier M. , Vidal S. , Gros P.
Genomics25:514-525(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
2.

"Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport."
Fleming M.D. , Romano M.A. , Su M.A. , Garrick L.M. , Garrick M.D. , Andrews N.C.
Proc. Natl. Acad. Sci. U.S.A.95:1148-1153(1998)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: DBA.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Embryo.
tissue: Hippocampus.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: FVB/N.
tissue: Kidney.
6.

"Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function."
Hubert N. , Hentze M.W.
Proc. Natl. Acad. Sci. U.S.A.99:12345-12350(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-80 (ISOFORMS 3/4);ALTERNATIVE SPLICING
strain: C57BL/6.
tissue: Duodenum.
7.

"Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron."
Canonne-Hergaux F. , Gruenheid S. , Ponka P. , Gros P.
Blood93:4406-4417(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
8.

"Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice."
Canonne-Hergaux F. , Zhang A.-S. , Ponka P. , Gros P.
Blood98:3823-3830(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
9.

"Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver."
Gunshin H. , Fujiwara Y. , Custodio A.O. , Direnzo C. , Robine S. , Andrews N.C.
J. Clin. Invest.115:1258-1266(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
10.

"Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1."
Ludwiczek S. , Theurl I. , Muckenthaler M.U. , Jakab M. , Mair S.M. , Theurl M. , Kiss J. , Paulmichl M. , Hentze M.W. , Ritter M. , Weiss G.
Nat. Med.13:448-454(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NIFEDIPINE TREATMENT
11.

"Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."
Foot N.J. , Dalton H.E. , Shearwin-Whyatt L.M. , Dorstyn L. , Tan S.S. , Yang B. , Kumar S.
Blood112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
12.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-564 AND SER-567;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene."
Fleming M.D. , Trenor C.C. III , Su M.A. , Foernzler D. , Beier D.R. , Dietrich W.F. , Andrews N.C.
Nat. Genet.16:383-386(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MK ARG-185

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